2-ETHYLBUTYRALDEHYDE Properties
Melting point: -89°C
Boiling point: 117 °C(lit.)
Density: 0.814 g/mL at 25 °C(lit.)
refractive index: n20/D 1.402(lit.)
FEMA: 2426 | 2-ETHYLBUTYRALDEHYDE
Flash point: 70 °F
storage temp.: Flammables area
Form: clear liquid
Color: Colorless to Light yellow
Odor: at 10.00 % in dipropylene glycol. sweet green ethereal fruity cocoa
Odor Type: green
Water Solubility: Soluble in ether and alcohols. Slightly soluble in water.
Sensitive: Air Sensitive
JECFA Number: 256
BRN: 1209330
Stability: Stable, but air sensitive. Flammable. Readily forms explosive mixtures with air. Incompatible with strong bases, strong reducing agents, oxidizing agents.
LogP: 1.73
CAS Reference: 97-96-1(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS): 2-ETHYLBUTYRALDEHYDE
FDA 21 CFR: 172.515
EWG's Food Scores: 1
FDA UNII: 676JY5569P
EPA Substance Registry System: Butanal, 2-ethyl- (97-96-1)

Introduction

2-ethylbutyraldehyde is an important chemical intermediate that can be used to synthesize a variety of organic compounds, such as rubber processing AIDS and dyes, and when mixed with triethylaluminum it can also be used as a two-component ignition for rocket propulsion systems.
2-ethylbutyraldehyde is also used as a spice ingredient in perfumes, soaps and cosmetics to give them their distinctive smell. For example, 2-ethylbutyraldehyde and lemongrass essential oil, sweet orange essential oil, nutmeg essential oil and ethyl benzoylacetate can be mixed to prepare a refreshing perfume, which can relax the whole body muscle system, resist stress, eliminate emotional anxiety, refresh the mind, and stay lasting 2-3 days.
2-ethylbutyraldehyde is also an important pharmaceutical material. For example, peramivir, a neuraminidase inhibitor, was synthesized from Vinlactam and 2-ethylbutyraldehyde through the steps of catalytic ring opening, amino protection and cyclization addition. The total yield was 52.7%, which was 28% higher than that in the literature. To investigate the efficacy of peramivir in prevention and treatment of mice artificially infected with H9N2 subtype avian influenza virus at different doses and administration modes, it was found that the protective effect of peramivir on infected mice was dose - and time-dependent. One-time intramuscular injection of 40mg/kg of peramivir has a protective rate of 100% in infected mice, and the efficacy of intramuscular injection is better within 2d after infection with the virus.